Cell atlas - PARP2 - The Human Protein Atlas

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PARP2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PARP2
Gene description	Poly (ADP-ribose) polymerase 2
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA052003
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

Nucleus (approved)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA052003	HeLa	Nucleus
	HPA052003	MCF7	Nucleus
	HPA052003	U-2 OS	Nucleus
	HPA052003	U-2 OS	Nucleoli

GENE INFORMATION
Gene name	PARP2 (HGNC Symbol)
Synonyms	ADPRTL2
Description	Poly (ADP-ribose) polymerase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20343582 - 20357905
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129484 (version 83.38)
Entrez gene	10038
UniProt	Q9UGN5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGN5
Antibodypedia	PARP2 antibodies

PROTEIN BROWSER

PARP2-001	PARP2-002	PARP2-003	PARP2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARP2-001 ENSP00000392972 ENST00000429687	Q9UGN5 [Direct mapping] Poly [ADP-ribose] polymerase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006471 [protein ADP-ribosylation] Show all	570 aa 64.8 kDa	No	0
PARP2-002 ENSP00000250416 ENST00000250416	Q9UGN5 [Direct mapping] Poly [ADP-ribose] polymerase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006471 [protein ADP-ribosylation] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	583 aa 66.2 kDa	No	0
PARP2-003 ENSP00000432283 ENST00000527915	G3V167 [Direct mapping] Poly (ADP-ribose) polymerase family, member 2, isoform CRA_a; Poly [ADP-ribose] polymerase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006471 [protein ADP-ribosylation] Show all	531 aa 60.2 kDa	No	0
PARP2-013 ENSP00000445524 ENST00000539930	H0YH02 [Direct mapping] Poly [ADP-ribose] polymerase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0006471 [protein ADP-ribosylation] Show all	177 aa 20.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.