Expression of PARP2 in cancer - Summary - The Human Protein Atlas

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PARP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PARP2
Gene description	Poly (ADP-ribose) polymerase 2
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA052003
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052003

GENE INFORMATION
Gene name	PARP2 (HGNC Symbol)
Synonyms	ADPRTL2
Description	Poly (ADP-ribose) polymerase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20343582 - 20357905
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129484 (version 83.38)
Entrez gene	10038
UniProt	Q9UGN5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UGN5
Antibodypedia	PARP2 antibodies

PROTEIN BROWSER

PARP2-001	PARP2-002	PARP2-003	PARP2-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PARP2-001 ENSP00000392972 ENST00000429687	Q9UGN5 [Direct mapping] Poly [ADP-ribose] polymerase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006471 [protein ADP-ribosylation] Show all	570 aa 64.8 kDa	No	0
PARP2-002 ENSP00000250416 ENST00000250416	Q9UGN5 [Direct mapping] Poly [ADP-ribose] polymerase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006471 [protein ADP-ribosylation] GO:0097191 [extrinsic apoptotic signaling pathway] Show all	583 aa 66.2 kDa	No	0
PARP2-003 ENSP00000432283 ENST00000527915	G3V167 [Direct mapping] Poly (ADP-ribose) polymerase family, member 2, isoform CRA_a; Poly [ADP-ribose] polymerase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006471 [protein ADP-ribosylation] Show all	531 aa 60.2 kDa	No	0
PARP2-013 ENSP00000445524 ENST00000539930	H0YH02 [Direct mapping] Poly [ADP-ribose] polymerase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0006471 [protein ADP-ribosylation] Show all	177 aa 20.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.