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This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005902 [microvillus] GO:0006338 [chromatin remodeling] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007219 [Notch signaling pathway] GO:0008134 [transcription factor binding] GO:0009653 [anatomical structure morphogenesis] GO:0010468 [regulation of gene expression] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0019904 [protein domain specific binding] GO:0021904 [dorsal/ventral neural tube patterning] GO:0030154 [cell differentiation] GO:0030324 [lung development] GO:0032355 [response to estradiol] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0035239 [tube morphogenesis] GO:0042445 [hormone metabolic process] GO:0042593 [glucose homeostasis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0045931 [positive regulation of mitotic cell cycle] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048665 [neuron fate specification] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051726 [regulation of cell cycle] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060487 [lung epithelial cell differentiation] GO:0060528 [secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development] GO:0060738 [epithelial-mesenchymal signaling involved in prostate gland development] GO:0060740 [prostate gland epithelium morphogenesis] GO:0060741 [prostate gland stromal morphogenesis] GO:0060743 [epithelial cell maturation involved in prostate gland development] GO:0061448 [connective tissue development] GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]