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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FOXA1
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FOXA1

Gene description

Forkhead box A1

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (prostate cancer)
HPA (cell line):Cell line enhanced (MCF7, PC-3, RT4, SK-BR-3, T-47d)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in prostate, urothelium, gastrointestinal tract, breast and respiratory epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA050505 , CAB011595
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PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY

HPA050505
CAB011595

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Breast, prostate, urothelial cancers, carcinoids along with few lung, cervical and endometrial cancers showed moderate to strong nuclear positivity. Other cancer tissues were in general weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several prostate and breast cancers showed weak to moderate nuclear positivity. Other cancer tissues were negative.

GENE INFORMATION

Gene name

FOXA1 (HGNC Symbol)

Synonyms

HNF3A

Description

Forkhead box A1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q21.1

Chromosome location (bp)

37589984 - 37596059

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000129514 (version 83.38)

Entrez gene

3169

UniProt

P55317 (UniProt - Evidence at protein level)

neXtProt

NX_P55317

Antibodypedia

FOXA1 antibodies

PROTEIN BROWSER

FOXA1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXA1-001
ENSP00000250448
ENST00000250448
P55317 [Direct mapping]
Hepatocyte nuclear factor 3-alpha
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Frameshift Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005902 [microvillus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0009653 [anatomical structure morphogenesis]
GO:0010468 [regulation of gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0019904 [protein domain specific binding]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0032355 [response to estradiol]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0035239 [tube morphogenesis]
GO:0042445 [hormone metabolic process]
GO:0042593 [glucose homeostasis]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0048665 [neuron fate specification]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060487 [lung epithelial cell differentiation]
GO:0060528 [secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development]
GO:0060738 [epithelial-mesenchymal signaling involved in prostate gland development]
GO:0060740 [prostate gland epithelium morphogenesis]
GO:0060741 [prostate gland stromal morphogenesis]
GO:0060743 [epithelial cell maturation involved in prostate gland development]
GO:0061448 [connective tissue development]
GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin]
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472 aa
49.1 kDa
No 0

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