Tissue expression of RNASE1 - Summary - The Human Protein Atlas

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RNASE1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RNASE1
Gene description	Ribonuclease, RNase A family, 1 (pancreatic)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in exocrine pancreas and gastrointestinal mucosa.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA001140
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RNASE1 (HGNC Symbol)
Synonyms	RAC1, RNS1
Description	Ribonuclease, RNase A family, 1 (pancreatic) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q11.2
Chromosome location (bp)	20801228 - 20803278
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129538 (version 83.38)
Entrez gene	6035
UniProt	P07998 (UniProt - Evidence at protein level)
neXtProt	NX_P07998
Antibodypedia	RNASE1 antibodies

PROTEIN BROWSER

RNASE1-001	RNASE1-002	RNASE1-003	RNASE1-004	RNASE1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASE1-001 ENSP00000381057 ENST00000397967	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-002 ENSP00000344193 ENST00000340900	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-003 ENSP00000381060 ENST00000397970	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-004 ENSP00000399493 ENST00000412779	P07998 [Direct mapping] Ribonuclease pancreatic W0UV93 [Target identity:100%; Query identity:100%] Ribonuclease A C1 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004522 [ribonuclease A activity] GO:0005515 [protein binding] GO:0070062 [extracellular exosome] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	156 aa 17.6 kDa	Yes	0
RNASE1-005 ENSP00000451058 ENST00000555698	G3V357 [Direct mapping] Ribonuclease pancreatic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004519 [endonuclease activity] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	116 aa 13 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.