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ARHGEF6

GENERAL INFORMATION

Gene name

 ARHGEF6

Gene description

 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in several different tissue types, most abundant in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA003578
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARHGEF6 (HGNC Symbol)

Synonyms

 alpha-PIX, alphaPIX, Cool-2, Cool2, KIAA0006, MRX46

Description

 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (HGNC Symbol)

Entrez gene summary

 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q26.3

Chromosome location (bp)

 136665547 - 136782088

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129675 (version 83.38)

Entrez gene

 9459

UniProt

 Q15052 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15052

Antibodypedia

 ARHGEF6 antibodies

PROTEIN BROWSER
ARHGEF6-001
ARHGEF6-002
ARHGEF6-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF6-001
ENSP00000250617
ENST00000250617
Q15052 [Direct mapping]
Rho guanine nucleotide exchange factor 6
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0006915 [apoptotic process]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0034329 [cell junction assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 776 aa
87.5 kDa 		No 0
ARHGEF6-002
ENSP00000359656
ENST00000370622
Q15052 [Direct mapping]
Rho guanine nucleotide exchange factor 6
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0034329 [cell junction assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 622 aa
70.8 kDa 		No 0
ARHGEF6-003
ENSP00000359654
ENST00000370620
Q15052 [Direct mapping]
Rho guanine nucleotide exchange factor 6
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0007254 [JNK cascade]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0034329 [cell junction assembly]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0097190 [apoptotic signaling pathway]
Show all
 622 aa
70.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.