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FGF13

GENERAL INFORMATION

Gene name

 FGF13

Gene description

 Fibroblast growth factor 13

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AF22, U-2197, WM-115)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues, including CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA002809
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002809

GENE INFORMATION

Gene name

 FGF13 (HGNC Symbol)

Synonyms

 FGF2, FHF2

Description

 Fibroblast growth factor 13 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

Chromosome

 X

Cytoband

Chromosome location (bp)

 138614731 - 139222777

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129682 (version 83.38)

Entrez gene

 2258

UniProt

 Q92913 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92913

Antibodypedia

 FGF13 antibodies

PROTEIN BROWSER
FGF13-001
FGF13-002
FGF13-003
FGF13-004
FGF13-005
FGF13-006
FGF13-007
FGF13-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF13-001
ENSP00000322390
ENST00000315930
Q92913 [Direct mapping]
Fibroblast growth factor 13
A8K1P5 [Target identity:100%; Query identity:100%]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0008083 [growth factor activity]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0021766 [hippocampus development]
GO:0021795 [cerebral cortex cell migration]
GO:0030175 [filopodium]
GO:0030295 [protein kinase activator activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032147 [activation of protein kinase activity]
GO:0043005 [neuron projection]
GO:0044325 [ion channel binding]
GO:0045200 [establishment of neuroblast polarity]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0048671 [negative regulation of collateral sprouting]
GO:0072659 [protein localization to plasma membrane]
Show all
 245 aa
27.6 kDa 		No 0
FGF13-002
ENSP00000303391
ENST00000305414
Q92913 [Direct mapping]
Fibroblast growth factor 13
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0008083 [growth factor activity]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0021766 [hippocampus development]
GO:0021795 [cerebral cortex cell migration]
GO:0030175 [filopodium]
GO:0030295 [protein kinase activator activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032147 [activation of protein kinase activity]
GO:0043005 [neuron projection]
GO:0044325 [ion channel binding]
GO:0045200 [establishment of neuroblast polarity]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0048671 [negative regulation of collateral sprouting]
GO:0072659 [protein localization to plasma membrane]
Show all
 192 aa
21.6 kDa 		No 0
FGF13-003
ENSP00000396198
ENST00000436198
Q92913 [Direct mapping]
Fibroblast growth factor 13
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0008083 [growth factor activity]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0021766 [hippocampus development]
GO:0021795 [cerebral cortex cell migration]
GO:0030175 [filopodium]
GO:0030295 [protein kinase activator activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032147 [activation of protein kinase activity]
GO:0043005 [neuron projection]
GO:0044325 [ion channel binding]
GO:0045200 [establishment of neuroblast polarity]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0048671 [negative regulation of collateral sprouting]
GO:0072659 [protein localization to plasma membrane]
Show all
 255 aa
28.8 kDa 		No 0
FGF13-004
ENSP00000411999
ENST00000448673
B1B1H9 [Direct mapping]
Fibroblast growth factor 13
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005576 [extracellular region]
GO:0008083 [growth factor activity]
Show all
 98 aa
11.2 kDa 		No 0
FGF13-005
ENSP00000406916
ENST00000455663
B1AJW0 [Direct mapping]
Fibroblast growth factor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0005576 [extracellular region]
GO:0008083 [growth factor activity]
Show all
 207 aa
23.7 kDa 		No 0
FGF13-006
ENSP00000388688
ENST00000421460
A0A0C4DG13 [Direct mapping]
Fibroblast growth factor 13
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 43 aa
5.1 kDa 		No 0
FGF13-007
ENSP00000487411
ENST00000626909
Q92913 [Direct mapping]
Fibroblast growth factor 13
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0008083 [growth factor activity]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0021766 [hippocampus development]
GO:0021795 [cerebral cortex cell migration]
GO:0030175 [filopodium]
GO:0030295 [protein kinase activator activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032147 [activation of protein kinase activity]
GO:0043005 [neuron projection]
GO:0044325 [ion channel binding]
GO:0045200 [establishment of neuroblast polarity]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0048671 [negative regulation of collateral sprouting]
GO:0072659 [protein localization to plasma membrane]
Show all
 199 aa
22.3 kDa 		No 0
FGF13-201
ENSP00000409276
ENST00000441825
Q92913 [Direct mapping]
Fibroblast growth factor 13
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0001764 [neuron migration]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0007399 [nervous system development]
GO:0007612 [learning]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0008083 [growth factor activity]
GO:0014704 [intercalated disc]
GO:0017080 [sodium channel regulator activity]
GO:0021766 [hippocampus development]
GO:0021795 [cerebral cortex cell migration]
GO:0030175 [filopodium]
GO:0030295 [protein kinase activator activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0032147 [activation of protein kinase activity]
GO:0043005 [neuron projection]
GO:0044325 [ion channel binding]
GO:0045200 [establishment of neuroblast polarity]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0048671 [negative regulation of collateral sprouting]
GO:0072659 [protein localization to plasma membrane]
Show all
 226 aa
25.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.