Expression of TMEM8A in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

TMEM8A

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM8A
Gene description	Transmembrane protein 8A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA051281
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051281

GENE INFORMATION
Gene name	TMEM8A (HGNC Symbol)
Synonyms	M83, TMEM6, TMEM8
Description	Transmembrane protein 8A (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	370773 - 387113
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129925 (version 83.38)
Entrez gene	58986
UniProt	Q9HCN3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCN3
Antibodypedia	TMEM8A antibodies

PROTEIN BROWSER

TMEM8A-001	TMEM8A-002	TMEM8A-005	TMEM8A-006	TMEM8A-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM8A-001 ENSP00000401338 ENST00000431232	Q9HCN3 [Direct mapping] Transmembrane protein 8A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	771 aa 84.8 kDa	Yes	7
TMEM8A-002 ENSP00000250930 ENST00000250930	K4DI83 [Direct mapping] Transmembrane protein 8 (Five membrane-spanning domains), isoform CRA_a; Transmembrane protein 8A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	578 aa 64.4 kDa	No	7
TMEM8A-005 ENSP00000397620 ENST00000424078	H0Y5B2 [Direct mapping] Transmembrane protein 8A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	239 aa 26.9 kDa	No	6
TMEM8A-006 ENSP00000401931 ENST00000448854	H7C1S0 [Direct mapping] Transmembrane protein 8A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] Show all	243 aa 27.4 kDa	No	5
TMEM8A-008 ENSP00000410987 ENST00000427313	C9J8D7 [Direct mapping] Transmembrane protein 8A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] Show all	21 aa 2.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.