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Positivity in plasma and cytoplasmic and membranous expression in glandular cells in gastrointestinal tract and hepatocytes.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Cancer tissues showed weak to moderate cytoplasmic immunoreactivity. Malignant gliomas, lymphomas and melanomas were negative.
GENE INFORMATION
Gene name
LBP (HGNC Symbol)
Synonyms
BPIFD2
Description
Lipopolysaccharide binding protein (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]