Cell atlas - SYT5 - The Human Protein Atlas

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SYT5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SYT5
Gene description	Synaptotagmin V
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HMC-1, EFO-21, K-562, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, EFO-21, K-562, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SYT5
Synonyms
Description	Synaptotagmin V (HGNC Symbol)
Entrez gene summary	Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	55171199 - 55180441
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129990 (version 83.38)
Entrez gene	6861
UniProt	O00445 (UniProt - Evidence at transcript level)
neXtProt	NX_O00445
Antibodypedia	SYT5 antibodies

PROTEIN BROWSER

SYT5-001	SYT5-002	SYT5-003	SYT5-004	SYT5-005	SYT5-010	SYT5-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYT5-001 ENSP00000346265 ENST00000354308	O00445 [Direct mapping] Synaptotagmin-5 A0A024R4N8 [Target identity:100%; Query identity:100%] Synaptotagmin V, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0031045 [dense core granule] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] GO:0048471 [perinuclear region of cytoplasm] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0050796 [regulation of insulin secretion] GO:0055038 [recycling endosome membrane] Show all	386 aa 42.9 kDa	No	1
SYT5-002 ENSP00000442896 ENST00000537500	O00445 [Direct mapping] Synaptotagmin-5 A0A024R4N8 [Target identity:100%; Query identity:100%] Synaptotagmin V, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0050796 [regulation of insulin secretion] GO:0055038 [recycling endosome membrane] Show all	386 aa 42.9 kDa	No	1
SYT5-003 ENSP00000465576 ENST00000590851	O00445 [Direct mapping] Synaptotagmin-5 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0006112 [energy reserve metabolic process] GO:0007268 [synaptic transmission] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030054 [cell junction] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0044281 [small molecule metabolic process] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] GO:0050796 [regulation of insulin secretion] GO:0055038 [recycling endosome membrane] Show all	382 aa 42.5 kDa	No	0
SYT5-004 ENSP00000465110 ENST00000592470	K7EJC4 [Direct mapping] Synaptotagmin-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	152 aa 16.5 kDa	No	1
SYT5-005 ENSP00000467685 ENST00000589172	K7EQ59 [Direct mapping] Synaptotagmin-5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	154 aa 16.7 kDa	No	1
SYT5-010 ENSP00000465304 ENST00000587067	K7EJS7 [Direct mapping] Synaptotagmin-5 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	67 aa 7.6 kDa	No	0
SYT5-011 ENSP00000469874 ENST00000590859	M0QYJ7 [Direct mapping] Synaptotagmin-5 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005544 [calcium-dependent phospholipid binding] GO:0005886 [plasma membrane] GO:0016079 [synaptic vesicle exocytosis] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0019905 [syntaxin binding] GO:0030276 [clathrin binding] GO:0030672 [synaptic vesicle membrane] GO:0048488 [synaptic vesicle endocytosis] GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter] Show all	22 aa 2.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.