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SYT5

GENERAL INFORMATION

Gene name

 SYT5

Gene description

 Synaptotagmin V

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:Group enriched (brain, caudate, hippocampus, pituitary gland)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, hippocampus, pituitary gland)

GENE INFORMATION

Gene name

 SYT5

Synonyms

Description

 Synaptotagmin V (HGNC Symbol)

Entrez gene summary

 Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative regulators of vesicle fusion, allowing fusion in the presence of calcium, and as calcium receptors or sensor molecules (summary by Hudson and Birnbaum, 1995 [PubMed 7597049]).[supplied by OMIM, Feb 2011]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55171199 - 55180441

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000129990 (version 83.38)

Entrez gene

 6861

UniProt

 O00445 (UniProt - Evidence at transcript level)

neXtProt

 NX_O00445

Antibodypedia

 SYT5 antibodies

PROTEIN BROWSER
SYT5-001
SYT5-002
SYT5-003
SYT5-004
SYT5-005
SYT5-010
SYT5-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYT5-001
ENSP00000346265
ENST00000354308
O00445 [Direct mapping]
Synaptotagmin-5
A0A024R4N8 [Target identity:100%; Query identity:100%]
Synaptotagmin V, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0031045 [dense core granule]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050796 [regulation of insulin secretion]
GO:0055038 [recycling endosome membrane]
Show all
 386 aa
42.9 kDa 		No 1
SYT5-002
ENSP00000442896
ENST00000537500
O00445 [Direct mapping]
Synaptotagmin-5
A0A024R4N8 [Target identity:100%; Query identity:100%]
Synaptotagmin V, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050796 [regulation of insulin secretion]
GO:0055038 [recycling endosome membrane]
Show all
 386 aa
42.9 kDa 		No 1
SYT5-003
ENSP00000465576
ENST00000590851
O00445 [Direct mapping]
Synaptotagmin-5
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007268 [synaptic transmission]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030054 [cell junction]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0044281 [small molecule metabolic process]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
GO:0050796 [regulation of insulin secretion]
GO:0055038 [recycling endosome membrane]
Show all
 382 aa
42.5 kDa 		No 0
SYT5-004
ENSP00000465110
ENST00000592470
K7EJC4 [Direct mapping]
Synaptotagmin-5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 152 aa
16.5 kDa 		No 1
SYT5-005
ENSP00000467685
ENST00000589172
K7EQ59 [Direct mapping]
Synaptotagmin-5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 154 aa
16.7 kDa 		No 1
SYT5-010
ENSP00000465304
ENST00000587067
K7EJS7 [Direct mapping]
Synaptotagmin-5
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 67 aa
7.6 kDa 		No 0
SYT5-011
ENSP00000469874
ENST00000590859
M0QYJ7 [Direct mapping]
Synaptotagmin-5
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005886 [plasma membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0017158 [regulation of calcium ion-dependent exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 22 aa
2.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.