Cell atlas - TNNI3 - The Human Protein Atlas

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TNNI3

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Vesicles

Human cell
	Cytosol
	Vesicles

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GENERAL INFORMATION
Gene name	TNNI3
Gene description	Troponin I type 3 (cardiac)
Protein class	Candidate cardiovascular disease genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to vesicles.
RNA cell category	Cell line enhanced (K-562, HMC-1, HEK 293)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046428
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (K-562, HMC-1, HEK 293) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to vesicles.

Main location

Cytosol (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046428	HEK 293	Vesicles
	HPA046428	HEK 293	Cytosol
	HPA046428	SH-SY5Y	Cytosol
	HPA046428	U-2 OS	Vesicles
	HPA046428	U-2 OS	Cytosol

GENE INFORMATION
Gene name	TNNI3 (HGNC Symbol)
Synonyms	CMD2A, CMH7, TNNC1
Description	Troponin I type 3 (cardiac) (HGNC Symbol)
Entrez gene summary	Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	55151767 - 55157773
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000129991 (version 83.38)
Entrez gene	7137
UniProt	P19429 (UniProt - Evidence at protein level)
neXtProt	NX_P19429
Antibodypedia	TNNI3 antibodies

PROTEIN BROWSER

TNNI3-001	TNNI3-005	TNNI3-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNNI3-001 ENSP00000341838 ENST00000344887	P19429 [Direct mapping] Troponin I, cardiac muscle Q6FGX2 [Target identity:100%; Query identity:100%] TNNI3 protein; Troponin I type 3 (Cardiac); Troponin I, cardiac; Troponin I, cardiac variant Show all	Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001570 [vasculogenesis] GO:0001980 [regulation of systemic arterial blood pressure by ischemic conditions] GO:0003009 [skeletal muscle contraction] GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0006874 [cellular calcium ion homeostasis] GO:0006937 [regulation of muscle contraction] GO:0006940 [regulation of smooth muscle contraction] GO:0006941 [striated muscle contraction] GO:0007507 [heart development] GO:0019855 [calcium channel inhibitor activity] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030016 [myofibril] GO:0030017 [sarcomere] GO:0030049 [muscle filament sliding] GO:0030172 [troponin C binding] GO:0031014 [troponin T binding] GO:0032780 [negative regulation of ATPase activity] GO:0043292 [contractile fiber] GO:0046872 [metal ion binding] GO:0048306 [calcium-dependent protein binding] GO:0055010 [ventricular cardiac muscle tissue morphogenesis] GO:0060047 [heart contraction] GO:0060048 [cardiac muscle contraction] Show all	210 aa 24 kDa	No	0
TNNI3-005 ENSP00000465258 ENST00000586858	K7EJP0 [Direct mapping] Troponin I, cardiac muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.4 kDa	No	0
TNNI3-006 ENSP00000466729 ENST00000588882	K7EN02 [Direct mapping] Troponin I, cardiac muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] Show all	185 aa 21.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.