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Few embryonal carcinomas, liver and stomach cancers along with squamous cell carcinomas of head & neck showed weak cytoplasmic immunoreactivity. Remaining cancer tissues were negative.
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
P19429 [Direct mapping] Troponin I, cardiac muscle Q6FGX2 [Target identity:100%; Query identity:100%] TNNI3 protein; Troponin I type 3 (Cardiac); Troponin I, cardiac; Troponin I, cardiac variant
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Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)