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PUDP

GENERAL INFORMATION

Gene name

 PUDP

Gene description

 Pseudouridine 5'-phosphatase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and pancreatic cancer (unfavourable).
Thyroid cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PUDP (HGNC Symbol)

Synonyms

 DXF68S1E, FAM16AX, GS1, HDHD1, HDHD1A

Description

 Pseudouridine 5'-phosphatase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The encoded protein has no known biological function. This gene has a pseudogene on chromosome 1. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

Chromosome

 X

Cytoband

 p22.31

Chromosome location (bp)

 7048920 - 7148190

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130021 (version 83.38)

Entrez gene

 8226

UniProt

 Q08623 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08623

Antibodypedia

 PUDP antibodies

PROTEIN BROWSER
PUDP-001
PUDP-003
PUDP-004
PUDP-005
PUDP-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PUDP-001
ENSP00000370467
ENST00000381077
Q08623 [Direct mapping]
Pseudouridine-5'-phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0009117 [nucleotide metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1990738 [pseudouridine 5'-phosphatase activity]
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 228 aa
25.2 kDa 		No 0
PUDP-003
ENSP00000430995
ENST00000486446
E7EVH9 [Direct mapping]
Pseudouridine-5'-phosphatase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 191 aa
21.5 kDa 		No 0
PUDP-004
ENSP00000406260
ENST00000412827
Q08623 [Direct mapping]
Pseudouridine-5'-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0009117 [nucleotide metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1990738 [pseudouridine 5'-phosphatase activity]
Show all
 185 aa
20.5 kDa 		No 0
PUDP-005
ENSP00000396452
ENST00000424830
Q08623 [Direct mapping]
Pseudouridine-5'-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0008150 [biological_process]
GO:0008152 [metabolic process]
GO:0009117 [nucleotide metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1990738 [pseudouridine 5'-phosphatase activity]
Show all
 251 aa
27.6 kDa 		No 0
PUDP-201
ENSP00000441208
ENST00000540122
Q08623 [Direct mapping]
Pseudouridine-5'-phosphatase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0008150 [biological_process]
GO:0009117 [nucleotide metabolic process]
GO:0016311 [dephosphorylation]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
GO:1990738 [pseudouridine 5'-phosphatase activity]
Show all
 208 aa
23.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.