Expression of PHF10 in cancer - Summary - The Human Protein Atlas

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PHF10

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PHF10
Gene description	PHD finger protein 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA055649
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), renal cancer (unfavourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055649

GENE INFORMATION
Gene name	PHF10 (HGNC Symbol)
Synonyms	BAF45a, FLJ10975, XAP135
Description	PHD finger protein 10 (HGNC Symbol)
Entrez gene summary	This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	169703905 - 169725566
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130024 (version 83.38)
Entrez gene	55274
UniProt	Q8WUB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUB8
Antibodypedia	PHF10 antibodies

PROTEIN BROWSER

PHF10-001	PHF10-002	PHF10-201	PHF10-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHF10-001 ENSP00000341805 ENST00000339209	Q8WUB8 [Direct mapping] PHD finger protein 10 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0008270 [zinc ion binding] GO:0071564 [npBAF complex] Show all	498 aa 56.1 kDa	No	0
PHF10-002 ENSP00000355743 ENST00000366780	Q8WUB8 [Direct mapping] PHD finger protein 10 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0008270 [zinc ion binding] GO:0071564 [npBAF complex] Show all	496 aa 55.8 kDa	No	0
PHF10-201 ENSP00000479515 ENST00000612128	S5FZ81 [Direct mapping] PHD finger protein 10; PHF10 isoform Sl Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		377 aa 42.6 kDa	No	0
PHF10-202 ENSP00000484117 ENST00000621772	Q8WUB8 [Direct mapping] PHD finger protein 10 S5FMB0 [Target identity:100%; Query identity:100%] PHF10 isoform Ps Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007399 [nervous system development] GO:0008270 [zinc ion binding] GO:0071564 [npBAF complex] Show all	451 aa 51.3 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.