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Colorectal cancers and cholangiocarcinomas along with several cases of stomach, cervical, ovarian and pancreatic cancers showed moderate to strong membranous and occasional cytoplasmic staining. Most remaining cancers were weakly stained or negative.
Most cancer tissues showed weak to moderate cytoplasmic and/or membranous immunoreactivity. Gliomas, lymphomas, melanomas and skin cancers were negative.
GENE INFORMATION
Gene name
KCNA5 (HGNC Symbol)
Synonyms
HK2, HPCN1, Kv1.5
Description
Potassium channel, voltage gated shaker related subfamily A, member 5 (HGNC Symbol)
Entrez gene summary
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]