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KCNA5

GENERAL INFORMATION

Gene name

 KCNA5

Gene description

 Potassium channel, voltage gated shaker related subfamily A, member 5

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (heart muscle)
GTEx:Tissue enhanced (heart muscle)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Membranous positivity in most glandular cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA021516 , CAB022562
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 KCNA5 (HGNC Symbol)

Synonyms

 HK2, HPCN1, Kv1.5

Description

 Potassium channel, voltage gated shaker related subfamily A, member 5 (HGNC Symbol)

Entrez gene summary

 Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]

Chromosome

 12

Cytoband

 p13.32

Chromosome location (bp)

 5043989 - 5046788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130037 (version 83.38)

Entrez gene

 3741

UniProt

 P22460 (UniProt - Evidence at protein level)

neXtProt

 NX_P22460

Antibodypedia

 KCNA5 antibodies

PROTEIN BROWSER
KCNA5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNA5-001
ENSP00000252321
ENST00000252321
P22460 [Direct mapping]
Potassium voltage-gated channel subfamily A member 5
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0001666 [response to hypoxia]
GO:0005102 [receptor binding]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005901 [caveola]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0007219 [Notch signaling pathway]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0009612 [response to mechanical stimulus]
GO:0010033 [response to organic substance]
GO:0014704 [intercalated disc]
GO:0015271 [outward rectifier potassium channel activity]
GO:0016020 [membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0019870 [potassium channel inhibitor activity]
GO:0019901 [protein kinase binding]
GO:0030018 [Z disc]
GO:0034705 [potassium channel complex]
GO:0042391 [regulation of membrane potential]
GO:0042542 [response to hydrogen peroxide]
GO:0043266 [regulation of potassium ion transport]
GO:0043267 [negative regulation of potassium ion transport]
GO:0045121 [membrane raft]
GO:0046691 [intracellular canaliculus]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050796 [regulation of insulin secretion]
GO:0051259 [protein oligomerization]
GO:0051260 [protein homooligomerization]
GO:0051393 [alpha-actinin binding]
GO:0051481 [negative regulation of cytosolic calcium ion concentration]
GO:0055075 [potassium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0055093 [response to hyperoxia]
GO:0060081 [membrane hyperpolarization]
GO:0060372 [regulation of atrial cardiac muscle cell membrane repolarization]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086050 [membrane repolarization during bundle of His cell action potential]
GO:0086052 [membrane repolarization during SA node cell action potential]
GO:0086087 [voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization]
GO:0086089 [voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization]
GO:0086090 [voltage-gated potassium channel activity involved in SA node cell action potential repolarization]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:1900087 [positive regulation of G1/S transition of mitotic cell cycle]
GO:2000288 [positive regulation of myoblast proliferation]
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 613 aa
67.2 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.