Cell atlas - GNL3L - The Human Protein Atlas

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GNL3L

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	GNL3L
Gene description	Guanine nucleotide binding protein-like 3 (nucleolar)-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA036315
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.

Main location

Nucleoli (supported)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036315	A-431	Nucleus
			Nucleoli
			Cytosol
	HPA036315	U-2 OS	Nucleus
			Nucleoli
			Cytosol
	HPA036315	U-251 MG	Nucleus
			Nucleoli
			Cytosol

GENE INFORMATION
Gene name	GNL3L (HGNC Symbol)
Synonyms	FLJ10613
Description	Guanine nucleotide binding protein-like 3 (nucleolar)-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	54530211 - 54561071
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130119 (version 83.38)
Entrez gene	54552
UniProt	Q9NVN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVN8
Antibodypedia	GNL3L antibodies

PROTEIN BROWSER

GNL3L-001	GNL3L-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNL3L-001 ENSP00000354091 ENST00000360845	Q9NVN8 [Direct mapping] Guanine nucleotide-binding protein-like 3-like protein A0A024R9Y6 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein-like 3 (Nucleolar)-like, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] Show all	582 aa 65.6 kDa	No	0
GNL3L-003 ENSP00000338573 ENST00000336470	Q9NVN8 [Direct mapping] Guanine nucleotide-binding protein-like 3-like protein A0A024R9Y6 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein-like 3 (Nucleolar)-like, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] Show all	582 aa 65.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.