Expression of GNL3L in cancer - Summary - The Human Protein Atlas

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GNL3L

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GNL3L
Gene description	Guanine nucleotide binding protein-like 3 (nucleolar)-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA036314 , HPA036315
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036314	HPA036315

GENE INFORMATION
Gene name	GNL3L (HGNC Symbol)
Synonyms	FLJ10613
Description	Guanine nucleotide binding protein-like 3 (nucleolar)-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	54530211 - 54561071
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130119 (version 83.38)
Entrez gene	54552
UniProt	Q9NVN8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVN8
Antibodypedia	GNL3L antibodies

PROTEIN BROWSER

GNL3L-001	GNL3L-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNL3L-001 ENSP00000354091 ENST00000360845	Q9NVN8 [Direct mapping] Guanine nucleotide-binding protein-like 3-like protein A0A024R9Y6 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein-like 3 (Nucleolar)-like, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] Show all	582 aa 65.6 kDa	No	0
GNL3L-003 ENSP00000338573 ENST00000336470	Q9NVN8 [Direct mapping] Guanine nucleotide-binding protein-like 3-like protein A0A024R9Y6 [Target identity:100%; Query identity:100%] Guanine nucleotide binding protein-like 3 (Nucleolar)-like, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003924 [GTPase activity] GO:0005515 [protein binding] GO:0005525 [GTP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0016020 [membrane] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] Show all	582 aa 65.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.