Cell atlas - APOC1 - The Human Protein Atlas

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APOC1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	APOC1
Gene description	Apolipoprotein C-I
Protein class	Cancer-related genes Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (Hep G2, SK-MEL-30, K-562)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, SK-MEL-30, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	APOC1
Synonyms
Description	Apolipoprotein C-I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	44914247 - 44919349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130208 (version 83.38)
Entrez gene	341
UniProt	P02654 (UniProt - Evidence at protein level)
neXtProt	NX_P02654
Antibodypedia	APOC1 antibodies

PROTEIN BROWSER

APOC1-001	APOC1-002	APOC1-003	APOC1-004	APOC1-005	APOC1-006	APOC1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOC1-001 ENSP00000465356 ENST00000588750	P02654 [Direct mapping] Apolipoprotein C-I Truncated apolipoprotein C-I A0A024R0T8 [Target identity:100%; Query identity:100%] Apolipoprotein C-I, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004859 [phospholipase inhibitor activity] GO:0005504 [fatty acid binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0006629 [lipid metabolic process] GO:0006641 [triglyceride metabolic process] GO:0008203 [cholesterol metabolic process] GO:0010873 [positive regulation of cholesterol esterification] GO:0010900 [negative regulation of phosphatidylcholine catabolic process] GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance] GO:0031210 [phosphatidylcholine binding] GO:0032374 [regulation of cholesterol transport] GO:0032375 [negative regulation of cholesterol transport] GO:0033344 [cholesterol efflux] GO:0033700 [phospholipid efflux] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0034369 [plasma lipoprotein particle remodeling] GO:0034375 [high-density lipoprotein particle remodeling] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0034382 [chylomicron remnant clearance] GO:0034447 [very-low-density lipoprotein particle clearance] GO:0042157 [lipoprotein metabolic process] GO:0042627 [chylomicron] GO:0043085 [positive regulation of catalytic activity] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045833 [negative regulation of lipid metabolic process] GO:0048261 [negative regulation of receptor-mediated endocytosis] GO:0050995 [negative regulation of lipid catabolic process] GO:0051005 [negative regulation of lipoprotein lipase activity] GO:0055102 [lipase inhibitor activity] GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity] GO:0070062 [extracellular exosome] Show all	83 aa 9.3 kDa	Yes	0
APOC1-002 ENSP00000468029 ENST00000588802	P02654 [Direct mapping] Apolipoprotein C-I Truncated apolipoprotein C-I A0A024R0T8 [Target identity:100%; Query identity:100%] Apolipoprotein C-I, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004859 [phospholipase inhibitor activity] GO:0005504 [fatty acid binding] GO:0005576 [extracellular region] GO:0005783 [endoplasmic reticulum] GO:0006629 [lipid metabolic process] GO:0010873 [positive regulation of cholesterol esterification] GO:0010900 [negative regulation of phosphatidylcholine catabolic process] GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance] GO:0031210 [phosphatidylcholine binding] GO:0032374 [regulation of cholesterol transport] GO:0032375 [negative regulation of cholesterol transport] GO:0033344 [cholesterol efflux] GO:0033700 [phospholipid efflux] GO:0034361 [very-low-density lipoprotein particle] GO:0034364 [high-density lipoprotein particle] GO:0034369 [plasma lipoprotein particle remodeling] GO:0034375 [high-density lipoprotein particle remodeling] GO:0034379 [very-low-density lipoprotein particle assembly] GO:0034382 [chylomicron remnant clearance] GO:0034447 [very-low-density lipoprotein particle clearance] GO:0042157 [lipoprotein metabolic process] GO:0042627 [chylomicron] GO:0043085 [positive regulation of catalytic activity] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0045833 [negative regulation of lipid metabolic process] GO:0048261 [negative regulation of receptor-mediated endocytosis] GO:0050995 [negative regulation of lipid catabolic process] GO:0051005 [negative regulation of lipoprotein lipase activity] GO:0055102 [lipase inhibitor activity] GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity] GO:0070062 [extracellular exosome] Show all	83 aa 9.3 kDa	Yes	0
APOC1-003 ENSP00000468276 ENST00000592535	K7ERI9 [Direct mapping] Apolipoprotein C-I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0042157 [lipoprotein metabolic process] Show all	77 aa 8.6 kDa	Yes	0
APOC1-004 ENSP00000467368 ENST00000592885	K7EPF9 [Direct mapping] Apolipoprotein C-I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0042157 [lipoprotein metabolic process] Show all	129 aa 14.3 kDa	Yes	0
APOC1-005 ENSP00000467504 ENST00000589781	K7EPR9 [Direct mapping] Apolipoprotein C-I Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.3 kDa	Yes	0
APOC1-006 ENSP00000466146 ENST00000586638	K7ELM9 [Direct mapping] Apolipoprotein C-I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0042157 [lipoprotein metabolic process] Show all	92 aa 10 kDa	Yes	0
APOC1-008 ENSP00000465710 ENST00000589078	K7EKP1 [Direct mapping] Apolipoprotein C-I Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0042157 [lipoprotein metabolic process] Show all	54 aa 5.8 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.