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APOC1

GENERAL INFORMATION

Gene name

 APOC1

Gene description

 Apolipoprotein C-I

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enhanced (Hep G2, K-562, SK-MEL-30)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Positivity in plasma

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA051518
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051518

GENE INFORMATION

Gene name

 APOC1

Synonyms

Description

 Apolipoprotein C-I (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 44914247 - 44919349

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130208 (version 83.38)

Entrez gene

 341

UniProt

 P02654 (UniProt - Evidence at protein level)

neXtProt

 NX_P02654

Antibodypedia

 APOC1 antibodies

PROTEIN BROWSER
APOC1-001
APOC1-002
APOC1-003
APOC1-004
APOC1-005
APOC1-006
APOC1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOC1-001
ENSP00000465356
ENST00000588750
P02654 [Direct mapping]
Apolipoprotein C-I Truncated apolipoprotein C-I
A0A024R0T8 [Target identity:100%; Query identity:100%]
Apolipoprotein C-I, isoform CRA_a
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005504 [fatty acid binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0006629 [lipid metabolic process]
GO:0006641 [triglyceride metabolic process]
GO:0008203 [cholesterol metabolic process]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010900 [negative regulation of phosphatidylcholine catabolic process]
GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance]
GO:0031210 [phosphatidylcholine binding]
GO:0032374 [regulation of cholesterol transport]
GO:0032375 [negative regulation of cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034369 [plasma lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034379 [very-low-density lipoprotein particle assembly]
GO:0034382 [chylomicron remnant clearance]
GO:0034447 [very-low-density lipoprotein particle clearance]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0043085 [positive regulation of catalytic activity]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0045833 [negative regulation of lipid metabolic process]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0051005 [negative regulation of lipoprotein lipase activity]
GO:0055102 [lipase inhibitor activity]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0070062 [extracellular exosome]
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 83 aa
9.3 kDa 		Yes 0
APOC1-002
ENSP00000468029
ENST00000588802
P02654 [Direct mapping]
Apolipoprotein C-I Truncated apolipoprotein C-I
A0A024R0T8 [Target identity:100%; Query identity:100%]
Apolipoprotein C-I, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005504 [fatty acid binding]
GO:0005576 [extracellular region]
GO:0005783 [endoplasmic reticulum]
GO:0006629 [lipid metabolic process]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010900 [negative regulation of phosphatidylcholine catabolic process]
GO:0010916 [negative regulation of very-low-density lipoprotein particle clearance]
GO:0031210 [phosphatidylcholine binding]
GO:0032374 [regulation of cholesterol transport]
GO:0032375 [negative regulation of cholesterol transport]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034369 [plasma lipoprotein particle remodeling]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0034379 [very-low-density lipoprotein particle assembly]
GO:0034382 [chylomicron remnant clearance]
GO:0034447 [very-low-density lipoprotein particle clearance]
GO:0042157 [lipoprotein metabolic process]
GO:0042627 [chylomicron]
GO:0043085 [positive regulation of catalytic activity]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0045833 [negative regulation of lipid metabolic process]
GO:0048261 [negative regulation of receptor-mediated endocytosis]
GO:0050995 [negative regulation of lipid catabolic process]
GO:0051005 [negative regulation of lipoprotein lipase activity]
GO:0055102 [lipase inhibitor activity]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0070062 [extracellular exosome]
Show all
 83 aa
9.3 kDa 		Yes 0
APOC1-003
ENSP00000468276
ENST00000592535
K7ERI9 [Direct mapping]
Apolipoprotein C-I
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0042157 [lipoprotein metabolic process]
Show all
 77 aa
8.6 kDa 		Yes 0
APOC1-004
ENSP00000467368
ENST00000592885
K7EPF9 [Direct mapping]
Apolipoprotein C-I
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0042157 [lipoprotein metabolic process]
Show all
 129 aa
14.3 kDa 		Yes 0
APOC1-005
ENSP00000467504
ENST00000589781
K7EPR9 [Direct mapping]
Apolipoprotein C-I
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.3 kDa 		Yes 0
APOC1-006
ENSP00000466146
ENST00000586638
K7ELM9 [Direct mapping]
Apolipoprotein C-I
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0042157 [lipoprotein metabolic process]
Show all
 92 aa
10 kDa 		Yes 0
APOC1-008
ENSP00000465710
ENST00000589078
K7EKP1 [Direct mapping]
Apolipoprotein C-I
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0042157 [lipoprotein metabolic process]
Show all
 54 aa
5.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.