Cell atlas - LRCH2 - The Human Protein Atlas

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LRCH2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Plasma membrane

Human cell
	Nucleoli
	Plasma Membrane

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GENERAL INFORMATION
Gene name	LRCH2
Gene description	Leucine-rich repeats and calponin homology (CH) domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the plasma membrane.
RNA cell category	Cell line enhanced (U-266/70)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA003233
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the plasma membrane.

Main location

Nucleoli (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA003233	A-431	Nucleoli
	HPA003233	U-2 OS	Nucleoli
	HPA003233	U-251 MG	Nucleoli
	HPA003233	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	LRCH2 (HGNC Symbol)
Synonyms	KIAA1495
Description	Leucine-rich repeats and calponin homology (CH) domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	115110616 - 115234072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130224 (version 83.38)
Entrez gene	57631
UniProt	Q5VUJ6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VUJ6
Antibodypedia	LRCH2 antibodies

PROTEIN BROWSER

LRCH2-001	LRCH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRCH2-001 ENSP00000325091 ENST00000317135	Q5VUJ6 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	765 aa 84.6 kDa	No	0
LRCH2-201 ENSP00000439366 ENST00000538422	Q5VUJ6 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	748 aa 82.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.