Expression of LRCH2 in cancer - Summary - The Human Protein Atlas

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LRCH2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRCH2
Gene description	Leucine-rich repeats and calponin homology (CH) domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (U-266/70)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA003233
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003233

GENE INFORMATION
Gene name	LRCH2 (HGNC Symbol)
Synonyms	KIAA1495
Description	Leucine-rich repeats and calponin homology (CH) domain containing 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the leucine-rich repeat and calponin homology domain-containing protein family. These family members contain multiple N-terminal leucine-rich repeats, in addition to a C-terminal calponin homology domain, a type of domain that mediates interactions with actin filaments. These proteins are conserved across animal species, and studies of a similar Drosophila protein indicate a function as a cytoskeletal scaffolding protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	q23
Chromosome location (bp)	115110616 - 115234072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130224 (version 83.38)
Entrez gene	57631
UniProt	Q5VUJ6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5VUJ6
Antibodypedia	LRCH2 antibodies

PROTEIN BROWSER

LRCH2-001	LRCH2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRCH2-001 ENSP00000325091 ENST00000317135	Q5VUJ6 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	765 aa 84.6 kDa	No	0
LRCH2-201 ENSP00000439366 ENST00000538422	Q5VUJ6 [Direct mapping] Leucine-rich repeat and calponin homology domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	748 aa 82.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.