Expression of DPP6 in cancer - Summary - The Human Protein Atlas

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DPP6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DPP6
Gene description	Dipeptidyl-peptidase 6
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enriched (NTERA-2)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, endometrium)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in processes in CNS and in smooth muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA050509
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050509

GENE INFORMATION
Gene name	DPP6 (HGNC Symbol)
Synonyms	DPPX
Description	Dipeptidyl-peptidase 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	7
Cytoband	q36.2
Chromosome location (bp)	153887097 - 154894285
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130226 (version 83.38)
Entrez gene	1804
UniProt	P42658 (UniProt - Evidence at protein level)
neXtProt	NX_P42658
Antibodypedia	DPP6 antibodies

PROTEIN BROWSER

DPP6-001	DPP6-002	DPP6-003	DPP6-006	DPP6-007	DPP6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPP6-001 ENSP00000385578 ENST00000404039	E9PF59 [Direct mapping] Dipeptidyl aminopeptidase-like protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] Show all	801 aa 91.2 kDa	No	1
DPP6-002 ENSP00000384393 ENST00000406326	Q8IYG9 [Direct mapping] DPP6 protein; Dipeptidyl aminopeptidase-like protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	353 aa 38.7 kDa	No	1
DPP6-003 ENSP00000367001 ENST00000377770	P42658 [Direct mapping] Dipeptidyl aminopeptidase-like protein 6 Show all	Enzymes Peptidases Serine-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008076 [voltage-gated potassium channel complex] GO:0008236 [serine-type peptidase activity] GO:0009986 [cell surface] GO:0015459 [potassium channel regulator activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019228 [neuronal action potential] GO:0042391 [regulation of membrane potential] GO:0043025 [neuronal cell body] GO:0043266 [regulation of potassium ion transport] GO:0043268 [positive regulation of potassium ion transport] GO:0070062 [extracellular exosome] GO:0072659 [protein localization to plasma membrane] GO:1901379 [regulation of potassium ion transmembrane transport] GO:1901381 [positive regulation of potassium ion transmembrane transport] Show all	865 aa 97.6 kDa	No	1
DPP6-006 ENSP00000328226 ENST00000332007	P42658 [Direct mapping] Dipeptidyl aminopeptidase-like protein 6 Show all	Enzymes Peptidases Serine-type peptidases Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0008076 [voltage-gated potassium channel complex] GO:0008236 [serine-type peptidase activity] GO:0015459 [potassium channel regulator activity] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] GO:0072659 [protein localization to plasma membrane] GO:1901379 [regulation of potassium ion transmembrane transport] Show all	803 aa 91.3 kDa	No	1
DPP6-007 ENSP00000397303 ENST00000427557	E9PDL2 [Direct mapping] Dipeptidyl aminopeptidase-like protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0016021 [integral component of membrane] Show all	758 aa 86.3 kDa	No	1
DPP6-201 ENSP00000477855 ENST00000619756	A0A087WTG7 [Direct mapping] Dipeptidyl aminopeptidase-like protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	291 aa 32.4 kDa	No	1

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The Human Protein Atlas

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