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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACE2
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACE2

Gene description

Angiotensin I converting enzyme 2

Protein class

Enzymes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Cell line enhanced (HaCaT)
HPA (normal tissue):Group enriched (duodenum, gallbladder, kidney, small intestine, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective membranous expression in renal tubules, intestinal tract, gallbladder and testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA000288 , CAB026174
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA000288
CAB026174

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Colorectal and renal cancers displayed moderate to strong cytoplasmic and membranous immunoreactivity. Cases of gastric and pancreatic cancers were moderately stained. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Renal cancers and a few cases of colorectal and liver cancers showed moderate to strong membranous immunoreactivity. The remaining cancer tissues were generally negative.

GENE INFORMATION

Gene name

ACE2

Synonyms

Description

Angiotensin I converting enzyme 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p22.2

Chromosome location (bp)

15561033 - 15602148

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000130234 (version 83.38)

Entrez gene

59272

UniProt

Q9BYF1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BYF1

Antibodypedia

ACE2 antibodies

PROTEIN BROWSER

ACE2-001
ACE2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACE2-001
ENSP00000252519
ENST00000252519
Q9BYF1 [Direct mapping]
Angiotensin-converting enzyme 2 Processed angiotensin-converting enzyme 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001817 [regulation of cytokine production]
GO:0001948 [glycoprotein binding]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0003051 [angiotensin-mediated drinking behavior]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032800 [receptor biosynthetic process]
GO:0042127 [regulation of cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0046718 [viral entry into host cell]
GO:0046813 [receptor-mediated virion attachment to host cell]
GO:0050727 [regulation of inflammatory response]
GO:0070062 [extracellular exosome]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903779 [regulation of cardiac conduction]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
805 aa
92.5 kDa
Yes 1
ACE2-201
ENSP00000389326
ENST00000427411
Q9BYF1 [Direct mapping]
Angiotensin-converting enzyme 2 Processed angiotensin-converting enzyme 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001817 [regulation of cytokine production]
GO:0001948 [glycoprotein binding]
GO:0002003 [angiotensin maturation]
GO:0002005 [angiotensin catabolic process in blood]
GO:0003051 [angiotensin-mediated drinking behavior]
GO:0003081 [regulation of systemic arterial blood pressure by renin-angiotensin]
GO:0004175 [endopeptidase activity]
GO:0004180 [carboxypeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008241 [peptidyl-dipeptidase activity]
GO:0008270 [zinc ion binding]
GO:0009986 [cell surface]
GO:0015827 [tryptophan transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019229 [regulation of vasoconstriction]
GO:0032800 [receptor biosynthetic process]
GO:0042127 [regulation of cell proliferation]
GO:0042312 [regulation of vasodilation]
GO:0044267 [cellular protein metabolic process]
GO:0045121 [membrane raft]
GO:0046718 [viral entry into host cell]
GO:0046813 [receptor-mediated virion attachment to host cell]
GO:0050727 [regulation of inflammatory response]
GO:0060452 [positive regulation of cardiac muscle contraction]
GO:0070062 [extracellular exosome]
GO:1903598 [positive regulation of gap junction assembly]
GO:1903779 [regulation of cardiac conduction]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
Show all
805 aa
92.5 kDa
Yes 1

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