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RNA tissue category: Group enriched (duodenum, gallbladder, kidney, small intestine, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)
GENE INFORMATION
Gene name
ACE2
Synonyms
Description
Angiotensin I converting enzyme 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008]