Expression of FAM98C in cancer - Summary - The Human Protein Atlas

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FAM98C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM98C
Gene description	Family with sequence similarity 98, member C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA040930 , HPA041730
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (unfavourable) and urothelial cancer (favourable).
Ovarian cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040930	HPA041730

GENE INFORMATION
Gene name	FAM98C (HGNC Symbol)
Synonyms	FLJ44669
Description	Family with sequence similarity 98, member C (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38403135 - 38409088
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130244 (version 83.38)
Entrez gene	147965
UniProt	Q17RN3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q17RN3
Antibodypedia	FAM98C antibodies

PROTEIN BROWSER

FAM98C-001	FAM98C-002	FAM98C-004	FAM98C-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM98C-001 ENSP00000252530 ENST00000252530	Q17RN3 [Direct mapping] Protein FAM98C Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] GO:0072669 [tRNA-splicing ligase complex] Show all	349 aa 37.3 kDa	No	0
FAM98C-002 ENSP00000467974 ENST00000588262	K7EQT7 [Direct mapping] Protein FAM98C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] GO:0072669 [tRNA-splicing ligase complex] Show all	186 aa 19.4 kDa	No	0
FAM98C-004 ENSP00000340348 ENST00000343358	Q17RN3 [Direct mapping] Protein FAM98C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] GO:0072669 [tRNA-splicing ligase complex] Show all	267 aa 28.7 kDa	No	0
FAM98C-007 ENSP00000467878 ENST00000589408	K7EQL1 [Direct mapping] Protein FAM98C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] GO:0072669 [tRNA-splicing ligase complex] Show all	181 aa 18.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.