Expression of NSUN5 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

NSUN5

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NSUN5
Gene description	NOP2/Sun domain family, member 5
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA020536
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and liver cancer (unfavourable).
Glioma p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020536

GENE INFORMATION
Gene name	NSUN5 (HGNC Symbol)
Synonyms	FLJ10267, NOL1R, NSUN5A, p120(NOL1), WBSCR20, WBSCR20A, Ynl022cL
Description	NOP2/Sun domain family, member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of an evolutionarily conserved family of proteins that may function as methyltransferases. This gene is located in a larger region of chromosome 7 that is deleted in Williams-Beuren syndrome, a multisystem developmental disorder. There are two pseudogenes for this gene located in the same region of chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	73302517 - 73308867
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130305 (version 83.38)
Entrez gene	55695
UniProt	Q96P11 (UniProt - Evidence at protein level)
neXtProt	NX_Q96P11
Antibodypedia	NSUN5 antibodies

PROTEIN BROWSER

NSUN5-001	NSUN5-002	NSUN5-004	NSUN5-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NSUN5-001 ENSP00000388464 ENST00000438747	Q96P11 [Direct mapping] Probable 28S rRNA (cytosine-C(5))-methyltransferase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	466 aa 50.4 kDa	No	0
NSUN5-002 ENSP00000252594 ENST00000252594	Q96P11 [Direct mapping] Probable 28S rRNA (cytosine-C(5))-methyltransferase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	429 aa 46.7 kDa	No	0
NSUN5-004 ENSP00000309126 ENST00000310326	Q96P11 [Direct mapping] Probable 28S rRNA (cytosine-C(5))-methyltransferase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	470 aa 51.1 kDa	No	0
NSUN5-005 ENSP00000393081 ENST00000428206	Q96P11 [Direct mapping] Probable 28S rRNA (cytosine-C(5))-methyltransferase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	391 aa 42.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.