Expression of COLGALT1 in cancer - Summary - The Human Protein Atlas

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COLGALT1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COLGALT1
Gene description	Collagen beta(1-O)galactosyltransferase 1
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047821
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), pancreatic cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047821

GENE INFORMATION
Gene name	COLGALT1 (HGNC Symbol)
Synonyms	FLJ22329, GLT25D1
Description	Collagen beta(1-O)galactosyltransferase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17555594 - 17583162
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130309 (version 83.38)
Entrez gene	79709
UniProt	Q8NBJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBJ5
Antibodypedia	COLGALT1 antibodies

PROTEIN BROWSER

COLGALT1-001	COLGALT1-005	COLGALT1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COLGALT1-001 ENSP00000252599 ENST00000252599	Q8NBJ5 [Direct mapping] Procollagen galactosyltransferase 1 Show all	Enzymes ENZYME proteins Transferases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005788 [endoplasmic reticulum lumen] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0050211 [procollagen galactosyltransferase activity] Show all	622 aa 71.6 kDa	Yes	0
COLGALT1-005 ENSP00000469817 ENST00000600474	M0QYH0 [Direct mapping] Procollagen galactosyltransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		138 aa 16.1 kDa	No	0
COLGALT1-007 ENSP00000468947 ENST00000597147	M0QX72 [Direct mapping] Procollagen galactosyltransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		218 aa 25.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.