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LSM7

GENERAL INFORMATION

Gene name

 LSM7

Gene description

 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041850
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), cervical cancer (favourable) and urothelial cancer (favourable).
Endometrial cancer p<0.001
Cervical cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041850

GENE INFORMATION

Gene name

 LSM7 (HGNC Symbol)

Synonyms

 YNL147W

Description

 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)

Entrez gene summary

 Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2321517 - 2328620

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130332 (version 83.38)

Entrez gene

 51690

UniProt

 Q9UK45 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK45

Antibodypedia

 LSM7 antibodies

PROTEIN BROWSER
LSM7-001
LSM7-002
LSM7-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM7-001
ENSP00000252622
ENST00000252622
Q9UK45 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm7
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005688 [U6 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0005829 [cytosol]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0017070 [U6 snRNA binding]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0097526 [spliceosomal tri-snRNP complex]
GO:1990726 [Lsm1-7-Pat1 complex]
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 103 aa
11.6 kDa 		No 0
LSM7-002
ENSP00000485007
ENST00000587502
A0A087X2I5 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0005732 [small nucleolar ribonucleoprotein complex]
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 49 aa
5.5 kDa 		No 0
LSM7-007
ENSP00000467145
ENST00000585409
K7ENY5 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 35 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.