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LSM7

GENERAL INFORMATION

Gene name

 LSM7

Gene description

 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041850
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 LSM7 (HGNC Symbol)

Synonyms

 YNL147W

Description

 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)

Entrez gene summary

 Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 2321517 - 2328620

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130332 (version 83.38)

Entrez gene

 51690

UniProt

 Q9UK45 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UK45

Antibodypedia

 LSM7 antibodies

PROTEIN BROWSER
LSM7-001
LSM7-002
LSM7-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM7-001
ENSP00000252622
ENST00000252622
Q9UK45 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm7
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005688 [U6 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0005732 [small nucleolar ribonucleoprotein complex]
GO:0005829 [cytosol]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0017070 [U6 snRNA binding]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0097526 [spliceosomal tri-snRNP complex]
GO:1990726 [Lsm1-7-Pat1 complex]
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 103 aa
11.6 kDa 		No 0
LSM7-002
ENSP00000485007
ENST00000587502
A0A087X2I5 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003723 [RNA binding]
GO:0005732 [small nucleolar ribonucleoprotein complex]
Show all
 49 aa
5.5 kDa 		No 0
LSM7-007
ENSP00000467145
ENST00000585409
K7ENY5 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.