Fields »
ABOUT
HELP
BLOG
MAS1

GENERAL INFORMATION

Gene name

 MAS1

Gene description

 MAS1 proto-oncogene, G protein-coupled receptor

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA013564
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Caudate

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 MAS1

Synonyms

Description

 MAS1 proto-oncogene, G protein-coupled receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]

Chromosome

 6

Cytoband

 q25.3

Chromosome location (bp)

 159906690 - 159916530

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130368 (version 83.38)

Entrez gene

 4142

UniProt

 P04201 (UniProt - Evidence at protein level)

neXtProt

 NX_P04201

Antibodypedia

 MAS1 antibodies

PROTEIN BROWSER
MAS1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAS1-001
ENSP00000252660
ENST00000252660
P04201 [Direct mapping]
Proto-oncogene Mas
W8W3P4 [Target identity:100%; Query identity:100%]
Mas-related G protein-coupled receptor A
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0001595 [angiotensin receptor activity]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0004930 [G-protein coupled receptor activity]
GO:0004945 [angiotensin type II receptor activity]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007283 [spermatogenesis]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0009653 [anatomical structure morphogenesis]
GO:0009986 [cell surface]
GO:0014823 [response to activity]
GO:0016021 [integral component of membrane]
GO:0017046 [peptide hormone binding]
GO:0021766 [hippocampus development]
GO:0034698 [response to gonadotropin]
GO:0038166 [angiotensin-activated signaling pathway]
GO:0042277 [peptide binding]
GO:0042493 [response to drug]
GO:0043434 [response to peptide hormone]
GO:0045740 [positive regulation of DNA replication]
GO:0050727 [regulation of inflammatory response]
GO:0060732 [positive regulation of inositol phosphate biosynthetic process]
GO:0070528 [protein kinase C signaling]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 325 aa
37.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.