Expression of MLLT4 in cancer - Summary

GENERAL INFORMATION
Gene name	MLLT4
Gene description	Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression. Also expressed in the cell membranes of several glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 5 antibodies. HPA030212 , HPA030213 , HPA030214 , HPA030215 , CAB013496
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA030212	HPA030213	HPA030214	HPA030215	CAB013496

GENE INFORMATION
Gene name	MLLT4 (HGNC Symbol)
Synonyms	AF-6, AF6
Description	Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-domain protein involved in signaling and organization of cell junctions during embryogenesis. It has also been identified as the fusion partner of acute lymphoblastic leukemia (ALL-1) gene, involved in acute myeloid leukemias with t(6;11)(q27;q23) translocation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, however, not all have been fully characterized.[provided by RefSeq, May 2011]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	167826922 - 167972023
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130396 (version 83.38)
Entrez gene	4301
UniProt	P55196 (UniProt - Evidence at protein level)
neXtProt	NX_P55196
Antibodypedia	MLLT4 antibodies

PROTEIN BROWSER

MLLT4-002	MLLT4-003	MLLT4-004	MLLT4-005	MLLT4-008	MLLT4-009	MLLT4-010	MLLT4-011	MLLT4-012	MLLT4-013	MLLT4-014	MLLT4-018	MLLT4-019	MLLT4-201	MLLT4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLLT4-002 ENSP00000341118 ENST00000344191	Q5TIG5 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0030054 [cell junction] Show all	1665 aa 189.2 kDa	No	0
MLLT4-003 ENSP00000383623 ENST00000400822	P55196 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008022 [protein C-terminus binding] GO:0017016 [Ras GTPase binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0043547 [positive regulation of GTPase activity] GO:0045216 [cell-cell junction organization] GO:0090557 [establishment of endothelial intestinal barrier] Show all	1834 aa 207.8 kDa	No	0
MLLT4-004 ENSP00000252692 ENST00000351017	J3KN01 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0030054 [cell junction] Show all	1831 aa 207.6 kDa	No	0
MLLT4-005 ENSP00000414675 ENST00000423229	H0Y7R8 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	389 aa 43.2 kDa	No	0
MLLT4-008 ENSP00000423035 ENST00000485634	H0Y948 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		191 aa 20.6 kDa	No	0
MLLT4-009 ENSP00000426462 ENST00000497596	H0YA98 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0030054 [cell junction] Show all	167 aa 18.8 kDa	No	0
MLLT4-010 ENSP00000383626 ENST00000400825	E9PFY5 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0030054 [cell junction] Show all	250 aa 29.1 kDa	No	0
MLLT4-011 ENSP00000383625 ENST00000400824	F8W9I4 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0030054 [cell junction] Show all	247 aa 28.9 kDa	No	0
MLLT4-012 ENSP00000424188 ENST00000476946	H0Y9I0 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		129 aa 16 kDa	No	0
MLLT4-013 ENSP00000404595 ENST00000447894	P55196 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008022 [protein C-terminus binding] GO:0017016 [Ras GTPase binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0043547 [positive regulation of GTPase activity] GO:0045216 [cell-cell junction organization] GO:0090557 [establishment of endothelial intestinal barrier] Show all	1824 aa 206.8 kDa	No	0
MLLT4-014 ENSP00000375956 ENST00000392108	P55196 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008022 [protein C-terminus binding] GO:0017016 [Ras GTPase binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0043547 [positive regulation of GTPase activity] GO:0045216 [cell-cell junction organization] GO:0090557 [establishment of endothelial intestinal barrier] Show all	1651 aa 187.7 kDa	No	0
MLLT4-018 ENSP00000421441 ENST00000507704	H0Y8L4 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		313 aa 36.4 kDa	No	0
MLLT4-019 ENSP00000422166 ENST00000515794	H0Y8U8 [Direct mapping] Afadin Show all	Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.1 kDa	No	0
MLLT4-201 ENSP00000355771 ENST00000366806	A8MQ02 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0005913 [cell-cell adherens junction] GO:0007165 [signal transduction] GO:0021537 [telencephalon development] GO:0021987 [cerebral cortex development] GO:0030054 [cell junction] GO:0034334 [adherens junction maintenance] GO:0045177 [apical part of cell] GO:0048854 [brain morphogenesis] GO:0048872 [homeostasis of number of cells] GO:0050839 [cell adhesion molecule binding] GO:0060019 [radial glial cell differentiation] GO:0060563 [neuroepithelial cell differentiation] GO:0070445 [regulation of oligodendrocyte progenitor proliferation] Show all	1781 aa 201.8 kDa	No	0
MLLT4-202 ENSP00000375960 ENST00000392112	P55196 [Direct mapping] Afadin Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005911 [cell-cell junction] GO:0005912 [adherens junction] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008022 [protein C-terminus binding] GO:0017016 [Ras GTPase binding] GO:0030054 [cell junction] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0043547 [positive regulation of GTPase activity] GO:0045216 [cell-cell junction organization] GO:0090557 [establishment of endothelial intestinal barrier] Show all	1743 aa 197.7 kDa	No	0