Cell atlas - TRPM4 - The Human Protein Atlas

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TRPM4

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Plasma membrane

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TRPM4
Gene description	Transient receptor potential cation channel, subfamily M, member 4
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & nucleoplasm.
RNA cell category	Cell line enhanced (RT4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Plasma membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA041169
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & nucleoplasm.

Main location

Nucleoplasm (approved), Plasma membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041169	A-431	Nucleoplasm
	HPA041169	A-431	Plasma membrane
	HPA041169	U-2 OS	Nucleoplasm
	HPA041169	U-2 OS	Plasma membrane
	HPA041169	U-251 MG	Nucleoplasm
	HPA041169	U-251 MG	Plasma membrane

GENE INFORMATION
Gene name	TRPM4 (HGNC Symbol)
Synonyms	FLJ20041
Description	Transient receptor potential cation channel, subfamily M, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49157741 - 49211836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130529 (version 83.38)
Entrez gene	54795
UniProt	Q8TD43 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD43
Antibodypedia	TRPM4 antibodies

PROTEIN BROWSER

TRPM4-001	TRPM4-002	TRPM4-006	TRPM4-009	TRPM4-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM4-001 ENSP00000252826 ENST00000252826	Q8TD43 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002407 [dendritic cell chemotaxis] GO:0002724 [regulation of T cell cytokine production] GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005262 [calcium channel activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016925 [protein sumoylation] GO:0034220 [ion transmembrane transport] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0061337 [cardiac conduction] GO:0070588 [calcium ion transmembrane transport] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	1214 aa 134.3 kDa	No	6
TRPM4-002 ENSP00000483753 ENST00000599628	A0A087X0Z3 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.6 kDa	No	0
TRPM4-006 ENSP00000407492 ENST00000427978	Q8TD43 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002407 [dendritic cell chemotaxis] GO:0002724 [regulation of T cell cytokine production] GO:0005227 [calcium activated cation channel activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016925 [protein sumoylation] GO:0034220 [ion transmembrane transport] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0061337 [cardiac conduction] GO:0070588 [calcium ion transmembrane transport] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	1069 aa 118.6 kDa	No	5
TRPM4-009 ENSP00000473231 ENST00000598691	M0R3H6 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002724 [regulation of T cell cytokine production] GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0061337 [cardiac conduction] GO:0098655 [cation transmembrane transport] Show all	156 aa 17.1 kDa	No	0
TRPM4-013 ENSP00000471236 ENST00000597316	M0R0H1 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002724 [regulation of T cell cytokine production] GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0061337 [cardiac conduction] GO:0098655 [cation transmembrane transport] Show all	51 aa 5.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.