Expression of TRPM4 in cancer - Summary

GENERAL INFORMATION
Gene name	TRPM4
Gene description	Transient receptor potential cation channel, subfamily M, member 4
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissue types, most abundant in gastrointestinal tract and prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA041169
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041169

GENE INFORMATION
Gene name	TRPM4 (HGNC Symbol)
Synonyms	FLJ20041
Description	Transient receptor potential cation channel, subfamily M, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49157741 - 49211836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130529 (version 83.38)
Entrez gene	54795
UniProt	Q8TD43 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TD43
Antibodypedia	TRPM4 antibodies

PROTEIN BROWSER

TRPM4-001	TRPM4-002	TRPM4-006	TRPM4-009	TRPM4-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM4-001 ENSP00000252826 ENST00000252826	Q8TD43 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002407 [dendritic cell chemotaxis] GO:0002724 [regulation of T cell cytokine production] GO:0005216 [ion channel activity] GO:0005227 [calcium activated cation channel activity] GO:0005262 [calcium channel activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016925 [protein sumoylation] GO:0034220 [ion transmembrane transport] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0061337 [cardiac conduction] GO:0070588 [calcium ion transmembrane transport] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	1214 aa 134.3 kDa	No	6
TRPM4-002 ENSP00000483753 ENST00000599628	A0A087X0Z3 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.6 kDa	No	0
TRPM4-006 ENSP00000407492 ENST00000427978	Q8TD43 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002407 [dendritic cell chemotaxis] GO:0002724 [regulation of T cell cytokine production] GO:0005227 [calcium activated cation channel activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0008284 [positive regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0016925 [protein sumoylation] GO:0034220 [ion transmembrane transport] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0055085 [transmembrane transport] GO:0061337 [cardiac conduction] GO:0070588 [calcium ion transmembrane transport] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	1069 aa 118.6 kDa	No	5
TRPM4-009 ENSP00000473231 ENST00000598691	M0R3H6 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002724 [regulation of T cell cytokine production] GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0061337 [cardiac conduction] GO:0098655 [cation transmembrane transport] Show all	156 aa 17.1 kDa	No	0
TRPM4-013 ENSP00000471236 ENST00000597316	M0R0H1 [Direct mapping] Transient receptor potential cation channel subfamily M member 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002724 [regulation of T cell cytokine production] GO:0005227 [calcium activated cation channel activity] GO:0016021 [integral component of membrane] GO:0042310 [vasoconstriction] GO:0042391 [regulation of membrane potential] GO:0061337 [cardiac conduction] GO:0098655 [cation transmembrane transport] Show all	51 aa 5.8 kDa	No	0