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HELZ2

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GENERAL INFORMATION

Gene name

 HELZ2

Gene description

 Helicase with zinc finger 2, transcriptional coactivator

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BJ hTERT+ SV40 Large T+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+ SV40 Large T+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HELZ2 (HGNC Symbol)

Synonyms

 KIAA1769, PDIP1, PRIC285

Description

 Helicase with zinc finger 2, transcriptional coactivator (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63558086 - 63574239

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130589 (version 83.38)

Entrez gene

 85441

UniProt

 Q9BYK8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYK8

Antibodypedia

 HELZ2 antibodies

PROTEIN BROWSER
HELZ2-001
HELZ2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HELZ2-001
ENSP00000393257
ENST00000427522
Q9BYK8 [Direct mapping]
Helicase with zinc finger domain 2
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0016020 [membrane]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 2080 aa
231.7 kDa 		No 0
HELZ2-003
ENSP00000417401
ENST00000467148
Q9BYK8 [Direct mapping]
Helicase with zinc finger domain 2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0016020 [membrane]
GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
Show all
 2649 aa
294.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.