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TNNI2

GENERAL INFORMATION

Gene name

 TNNI2

Gene description

 Troponin I type 2 (skeletal, fast)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, pancreatic cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (CAPAN-2, hTCEpi, T-47d)
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA055938 , CAB018697
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, pancreatic cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA055938
CAB018697

GENE INFORMATION

Gene name

 TNNI2 (HGNC Symbol)

Synonyms

 AMCD2B, DA2B, FSSV

Description

 Troponin I type 2 (skeletal, fast) (HGNC Symbol)

Entrez gene summary

 This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1838989 - 1841680

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130598 (version 83.38)

Entrez gene

 7136

UniProt

 P48788 (UniProt - Evidence at protein level)

neXtProt

 NX_P48788

Antibodypedia

 TNNI2 antibodies

PROTEIN BROWSER
TNNI2-001
TNNI2-002
TNNI2-003
TNNI2-201
TNNI2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNNI2-001
ENSP00000371331
ENST00000381906
P48788 [Direct mapping]
Troponin I, fast skeletal muscle
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
GO:0030049 [muscle filament sliding]
GO:0031014 [troponin T binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060048 [cardiac muscle contraction]
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 182 aa
21.3 kDa 		No 0
TNNI2-002
ENSP00000371336
ENST00000381911
P48788 [Direct mapping]
Troponin I, fast skeletal muscle
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0030049 [muscle filament sliding]
GO:0031014 [troponin T binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060048 [cardiac muscle contraction]
Show all
 182 aa
21.3 kDa 		No 0
TNNI2-003
ENSP00000371330
ENST00000381905
P48788 [Direct mapping]
Troponin I, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0030049 [muscle filament sliding]
GO:0031014 [troponin T binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060048 [cardiac muscle contraction]
Show all
 182 aa
21.4 kDa 		No 0
TNNI2-201
ENSP00000252898
ENST00000252898
P48788 [Direct mapping]
Troponin I, fast skeletal muscle
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0030049 [muscle filament sliding]
GO:0031014 [troponin T binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0060048 [cardiac muscle contraction]
Show all
 182 aa
21.3 kDa 		No 0
TNNI2-202
ENSP00000481242
ENST00000617947
A0A087WXS0 [Direct mapping]
Troponin I, fast skeletal muscle
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005861 [troponin complex]
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 182 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.