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P21 protein (Cdc42/Rac)-activated kinase 4 (HGNC Symbol)
Entrez gene summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
O96013 [Direct mapping] Serine/threonine-protein kinase PAK 4 A0A024R0L8 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O96013 [Direct mapping] Serine/threonine-protein kinase PAK 4 A0A024R0J1 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase
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Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O96013 [Direct mapping] Serine/threonine-protein kinase PAK 4 A0A024R0J1 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O96013 [Direct mapping] Serine/threonine-protein kinase PAK 4 A0A024R0L8 [Target identity:100%; Query identity:100%] Non-specific serine/threonine protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)