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PAK4

GENERAL INFORMATION

Gene name

 PAK4

Gene description

 P21 protein (Cdc42/Rac)-activated kinase 4

Protein class

 Enzymes
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
CAB025747 , CAB044670
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and prostate cancer (unfavourable).
Renal cancer p<0.001
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025747
CAB044670

GENE INFORMATION

Gene name

 PAK4

Synonyms

Description

 P21 protein (Cdc42/Rac)-activated kinase 4 (HGNC Symbol)

Entrez gene summary

 PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39125770 - 39182816

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130669 (version 83.38)

Entrez gene

 10298

UniProt

 O96013 (UniProt - Evidence at protein level)

neXtProt

 NX_O96013

Antibodypedia

 PAK4 antibodies

PROTEIN BROWSER
PAK4-001
PAK4-003
PAK4-004
PAK4-005
PAK4-006
PAK4-007
PAK4-010
PAK4-011
PAK4-015
PAK4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAK4-001
ENSP00000470284
ENST00000599470
O96013 [Direct mapping]
Serine/threonine-protein kinase PAK 4
A0A024R0L8 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 438 aa
48.3 kDa 		No 0
PAK4-003
ENSP00000351049
ENST00000358301
O96013 [Direct mapping]
Serine/threonine-protein kinase PAK 4
A0A024R0J1 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 591 aa
64.1 kDa 		No 0
PAK4-004
ENSP00000469413
ENST00000593690
O96013 [Direct mapping]
Serine/threonine-protein kinase PAK 4
A0A024R0J1 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 591 aa
64.1 kDa 		No 0
PAK4-005
ENSP00000471318
ENST00000602004
M0R0L9 [Direct mapping]
Serine/threonine-protein kinase PAK 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 182 aa
19.6 kDa 		No 0
PAK4-006
ENSP00000473215
ENST00000599657
M0R3G6 [Direct mapping]
Serine/threonine-protein kinase PAK 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 93 aa
10.1 kDa 		No 0
PAK4-007
ENSP00000472061
ENST00000597715
M0R1R1 [Direct mapping]
Serine/threonine-protein kinase PAK 4
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 149 aa
16.9 kDa 		No 0
PAK4-010
ENSP00000472862
ENST00000593480
M0R2X4 [Direct mapping]
Serine/threonine-protein kinase PAK 4
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 131 aa
14.5 kDa 		No 0
PAK4-011
ENSP00000326864
ENST00000321944
O96013 [Direct mapping]
Serine/threonine-protein kinase PAK 4
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 501 aa
54.9 kDa 		No 0
PAK4-015
ENSP00000471157
ENST00000599386
O96013 [Direct mapping]
Serine/threonine-protein kinase PAK 4
A0A024R0L8 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 438 aa
48.3 kDa 		No 0
PAK4-201
ENSP00000353625
ENST00000360442
O96013 [Direct mapping]
Serine/threonine-protein kinase PAK 4
A0A024R0J1 [Target identity:100%; Query identity:100%]
Non-specific serine/threonine protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007266 [Rho protein signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0008283 [cell proliferation]
GO:0016049 [cell growth]
GO:0016477 [cell migration]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030036 [actin cytoskeleton organization]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032147 [activation of protein kinase activity]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048365 [Rac GTPase binding]
Show all
 591 aa
64.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.