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GATA5

GENERAL INFORMATION

Gene name

 GATA5

Gene description

 GATA binding protein 5

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (stomach cancer)
HPA (cell line):Cell line enhanced (HEL, K-562, SiHa, T-47d)
HPA (normal tissue):Tissue enhanced (duodenum, small intestine, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 GATA5 (HGNC Symbol)

Synonyms

 bB379O24.1, GATAS

Description

 GATA binding protein 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 62463497 - 62475970

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130700 (version 83.38)

Entrez gene

 140628

UniProt

 Q9BWX5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWX5

Antibodypedia

 GATA5 antibodies

PROTEIN BROWSER
GATA5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GATA5-001
ENSP00000252997
ENST00000252997
Q9BWX5 [Direct mapping]
Transcription factor GATA-5
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001158 [enhancer sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045165 [cell fate commitment]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048468 [cell development]
GO:0048646 [anatomical structure formation involved in morphogenesis]
GO:0060575 [intestinal epithelial cell differentiation]
GO:0071773 [cellular response to BMP stimulus]
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 397 aa
41.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.