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ATPIF1

GENERAL INFORMATION

Gene name

 ATPIF1

Gene description

 ATPase inhibitory factor 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA027999
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and ovarian cancer (favourable).
Endometrial cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027999

GENE INFORMATION

Gene name

 ATPIF1 (HGNC Symbol)

Synonyms

 ATPI, ATPIP, IP, MGC1167, MGC8898

Description

 ATPase inhibitory factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitochondrial ATPase inhibitor. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.3

Chromosome location (bp)

 28236109 - 28246906

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130770 (version 83.38)

Entrez gene

 93974

UniProt

 Q9UII2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UII2

Antibodypedia

 ATPIF1 antibodies

PROTEIN BROWSER
ATPIF1-001
ATPIF1-002
ATPIF1-003
ATPIF1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATPIF1-001
ENSP00000335203
ENST00000335514
Q9UII2 [Direct mapping]
ATPase inhibitor, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005739 [mitochondrion]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006783 [heme biosynthetic process]
GO:0009986 [cell surface]
GO:0030218 [erythrocyte differentiation]
GO:0032780 [negative regulation of ATPase activity]
GO:0042030 [ATPase inhibitor activity]
GO:0042803 [protein homodimerization activity]
GO:0043532 [angiostatin binding]
GO:0045980 [negative regulation of nucleotide metabolic process]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051289 [protein homotetramerization]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051882 [mitochondrial depolarization]
GO:0072593 [reactive oxygen species metabolic process]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901030 [positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:1903214 [regulation of protein targeting to mitochondrion]
GO:1903578 [regulation of ATP metabolic process]
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 106 aa
12.2 kDa 		No 0
ATPIF1-002
ENSP00000437337
ENST00000465645
Q9UII2 [Direct mapping]
ATPase inhibitor, mitochondrial
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0004857 [enzyme inhibitor activity]
GO:0005516 [calmodulin binding]
GO:0005739 [mitochondrion]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006783 [heme biosynthetic process]
GO:0009986 [cell surface]
GO:0030218 [erythrocyte differentiation]
GO:0032780 [negative regulation of ATPase activity]
GO:0042030 [ATPase inhibitor activity]
GO:0042803 [protein homodimerization activity]
GO:0043532 [angiostatin binding]
GO:0045980 [negative regulation of nucleotide metabolic process]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051289 [protein homotetramerization]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051882 [mitochondrial depolarization]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:1903214 [regulation of protein targeting to mitochondrion]
GO:1903578 [regulation of ATP metabolic process]
Show all
 60 aa
6.6 kDa 		No 0
ATPIF1-003
ENSP00000435579
ENST00000497986
Q9UII2 [Direct mapping]
ATPase inhibitor, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001937 [negative regulation of endothelial cell proliferation]
GO:0004857 [enzyme inhibitor activity]
GO:0005516 [calmodulin binding]
GO:0005739 [mitochondrion]
GO:0005753 [mitochondrial proton-transporting ATP synthase complex]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006783 [heme biosynthetic process]
GO:0009986 [cell surface]
GO:0030218 [erythrocyte differentiation]
GO:0032780 [negative regulation of ATPase activity]
GO:0042030 [ATPase inhibitor activity]
GO:0042803 [protein homodimerization activity]
GO:0043532 [angiostatin binding]
GO:0045980 [negative regulation of nucleotide metabolic process]
GO:0051117 [ATPase binding]
GO:0051260 [protein homooligomerization]
GO:0051289 [protein homotetramerization]
GO:0051346 [negative regulation of hydrolase activity]
GO:0051882 [mitochondrial depolarization]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:1903214 [regulation of protein targeting to mitochondrion]
GO:1903578 [regulation of ATP metabolic process]
Show all
 71 aa
7.9 kDa 		No 0
ATPIF1-004
ENSP00000435341
ENST00000468425
A0A0B4J230 [Direct mapping]
ATPase inhibitor, mitochondrial
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004857 [enzyme inhibitor activity]
GO:0005739 [mitochondrion]
GO:0043086 [negative regulation of catalytic activity]
GO:0045980 [negative regulation of nucleotide metabolic process]
Show all
 75 aa
8.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.