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DNA (cytosine-5-)-methyltransferase 1 (HGNC Symbol)
Entrez gene summary
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
P26358 [Direct mapping] DNA (cytosine-5)-methyltransferase 1
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Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006306 [DNA methylation] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0009008 [DNA-methyltransferase activity] GO:0010216 [maintenance of DNA methylation] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016568 [chromatin modification] GO:0032776 [DNA methylation on cytosine] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0090116 [C-5 methylation of cytosine]
P26358 [Direct mapping] DNA (cytosine-5)-methyltransferase 1
Show all
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000792 [heterochromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003723 [RNA binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005657 [replication fork] GO:0005721 [pericentric heterochromatin] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006351 [transcription, DNA-templated] GO:0007420 [brain development] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0008327 [methyl-CpG binding] GO:0009008 [DNA-methyltransferase activity] GO:0009408 [response to heat] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010212 [response to ionizing radiation] GO:0010216 [maintenance of DNA methylation] GO:0010288 [response to lead ion] GO:0010424 [DNA methylation on cytosine within a CG sequence] GO:0010467 [gene expression] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0014823 [response to activity] GO:0016458 [gene silencing] GO:0016568 [chromatin modification] GO:0019904 [protein domain specific binding] GO:0030182 [neuron differentiation] GO:0030331 [estrogen receptor binding] GO:0031000 [response to caffeine] GO:0031667 [response to nutrient levels] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0032776 [DNA methylation on cytosine] GO:0033189 [response to vitamin A] GO:0033574 [response to testosterone] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0036276 [response to antidepressant] GO:0040029 [regulation of gene expression, epigenetic] GO:0042127 [regulation of cell proliferation] GO:0042493 [response to drug] GO:0042826 [histone deacetylase binding] GO:0043025 [neuronal cell body] GO:0043234 [protein complex] GO:0044026 [DNA hypermethylation] GO:0045322 [unmethylated CpG binding] GO:0045471 [response to ethanol] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046498 [S-adenosylhomocysteine metabolic process] GO:0046499 [S-adenosylmethioninamine metabolic process] GO:0046500 [S-adenosylmethionine metabolic process] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051718 [DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates] GO:0071230 [cellular response to amino acid stimulus] GO:0071284 [cellular response to lead ion] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0090116 [C-5 methylation of cytosine] GO:1990090 [cellular response to nerve growth factor stimulus]
P26358 [Direct mapping] DNA (cytosine-5)-methyltransferase 1
Show all
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006306 [DNA methylation] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0009008 [DNA-methyltransferase activity] GO:0010216 [maintenance of DNA methylation] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016568 [chromatin modification] GO:0032776 [DNA methylation on cytosine] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0090116 [C-5 methylation of cytosine]