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Cases of colorectal, breast, cervical, head and neck cancers and malignant lymphomas showed moderate nuclear positivity. Remaining malignancies were weakly stained or negative.
Malignant cells displayed weak to moderate nuclear positivity. Several malignant lymphomas, lung, gastric and colorectal cancers were strongly stained. Prostate cancers were negative.
GENE INFORMATION
Gene name
DNMT1 (HGNC Symbol)
Synonyms
CXXC9, DNMT, MCMT
Description
DNA (cytosine-5-)-methyltransferase 1 (HGNC Symbol)
Entrez gene summary
DNA (cytosine-5-)-methyltransferase 1 has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues. Aberrant methylation patterns are associated with certain human tumors and developmental abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
P26358 [Direct mapping] DNA (cytosine-5)-methyltransferase 1
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Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006306 [DNA methylation] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0009008 [DNA-methyltransferase activity] GO:0010216 [maintenance of DNA methylation] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016568 [chromatin modification] GO:0032776 [DNA methylation on cytosine] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0090116 [C-5 methylation of cytosine]
P26358 [Direct mapping] DNA (cytosine-5)-methyltransferase 1
Show all
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000792 [heterochromatin] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0003723 [RNA binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005657 [replication fork] GO:0005721 [pericentric heterochromatin] GO:0005737 [cytoplasm] GO:0006306 [DNA methylation] GO:0006351 [transcription, DNA-templated] GO:0007420 [brain development] GO:0007568 [aging] GO:0008134 [transcription factor binding] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0008327 [methyl-CpG binding] GO:0009008 [DNA-methyltransferase activity] GO:0009408 [response to heat] GO:0009636 [response to toxic substance] GO:0010033 [response to organic substance] GO:0010212 [response to ionizing radiation] GO:0010216 [maintenance of DNA methylation] GO:0010288 [response to lead ion] GO:0010424 [DNA methylation on cytosine within a CG sequence] GO:0010467 [gene expression] GO:0010468 [regulation of gene expression] GO:0010628 [positive regulation of gene expression] GO:0014823 [response to activity] GO:0016458 [gene silencing] GO:0016568 [chromatin modification] GO:0019904 [protein domain specific binding] GO:0030182 [neuron differentiation] GO:0030331 [estrogen receptor binding] GO:0031000 [response to caffeine] GO:0031667 [response to nutrient levels] GO:0032355 [response to estradiol] GO:0032496 [response to lipopolysaccharide] GO:0032776 [DNA methylation on cytosine] GO:0033189 [response to vitamin A] GO:0033574 [response to testosterone] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0036276 [response to antidepressant] GO:0040029 [regulation of gene expression, epigenetic] GO:0042127 [regulation of cell proliferation] GO:0042493 [response to drug] GO:0042826 [histone deacetylase binding] GO:0043025 [neuronal cell body] GO:0043234 [protein complex] GO:0044026 [DNA hypermethylation] GO:0045322 [unmethylated CpG binding] GO:0045471 [response to ethanol] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046498 [S-adenosylhomocysteine metabolic process] GO:0046499 [S-adenosylmethioninamine metabolic process] GO:0046500 [S-adenosylmethionine metabolic process] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0051718 [DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates] GO:0071230 [cellular response to amino acid stimulus] GO:0071284 [cellular response to lead ion] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:0090116 [C-5 methylation of cytosine] GO:1990090 [cellular response to nerve growth factor stimulus]
P26358 [Direct mapping] DNA (cytosine-5)-methyltransferase 1
Show all
Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003886 [DNA (cytosine-5-)-methyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006306 [DNA methylation] GO:0006351 [transcription, DNA-templated] GO:0008134 [transcription factor binding] GO:0008168 [methyltransferase activity] GO:0008270 [zinc ion binding] GO:0009008 [DNA-methyltransferase activity] GO:0010216 [maintenance of DNA methylation] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016568 [chromatin modification] GO:0032776 [DNA methylation on cytosine] GO:0040029 [regulation of gene expression, epigenetic] GO:0045814 [negative regulation of gene expression, epigenetic] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0051573 [negative regulation of histone H3-K9 methylation] GO:0090116 [C-5 methylation of cytosine]