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HSD17B3

GENERAL INFORMATION

Gene name

 HSD17B3

Gene description

 Hydroxysteroid (17-beta) dehydrogenase 3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in Leydig cells

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA056833
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 HSD17B3 (HGNC Symbol)

Synonyms

 SDR12C2

Description

 Hydroxysteroid (17-beta) dehydrogenase 3 (HGNC Symbol)

Entrez gene summary

 This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q22.32

Chromosome location (bp)

 96235306 - 96302152

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130948 (version 83.38)

Entrez gene

 3293

UniProt

 P37058 (UniProt - Evidence at protein level)

neXtProt

 NX_P37058

Antibodypedia

 HSD17B3 antibodies

PROTEIN BROWSER
HSD17B3-005
HSD17B3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HSD17B3-005
ENSP00000364412
ENST00000375263
P37058 [Direct mapping]
Testosterone 17-beta-dehydrogenase 3
Q6FH62 [Target identity:100%; Query identity:100%]
HSD17B3 protein; Hydroxysteroid (17-beta) dehydrogenase 3
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0006702 [androgen biosynthetic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030539 [male genitalia development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0047045 [testosterone 17-beta-dehydrogenase (NADP+) activity]
GO:0055114 [oxidation-reduction process]
GO:0061370 [testosterone biosynthetic process]
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 310 aa
34.5 kDa 		No 1
HSD17B3-201
ENSP00000364411
ENST00000375262
P37058 [Direct mapping]
Testosterone 17-beta-dehydrogenase 3
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0006702 [androgen biosynthetic process]
GO:0008152 [metabolic process]
GO:0008202 [steroid metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0030539 [male genitalia development]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0047045 [testosterone 17-beta-dehydrogenase (NADP+) activity]
GO:0055114 [oxidation-reduction process]
GO:0061370 [testosterone biosynthetic process]
Show all
 260 aa
29.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.