Tissue expression of AKAP12 - Summary - The Human Protein Atlas

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AKAP12

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AKAP12
Gene description	A kinase (PRKA) anchor protein 12
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in seminiferous ducts, endothelial cells and connective tissue.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 3 antibodies. HPA006344 , HPA056230 , CAB026379
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	AKAP12 (HGNC Symbol)
Synonyms	AKAP250, SSeCKS
Description	A kinase (PRKA) anchor protein 12 (HGNC Symbol)
Entrez gene summary	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q25.1
Chromosome location (bp)	151239999 - 151358557
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131016 (version 83.38)
Entrez gene	9590
UniProt	Q02952 (UniProt - Evidence at protein level)
neXtProt	NX_Q02952
Antibodypedia	AKAP12 antibodies

PROTEIN BROWSER

AKAP12-001	AKAP12-002	AKAP12-201	AKAP12-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AKAP12-001 ENSP00000253332 ENST00000253332	Q02952 [Direct mapping] A-kinase anchor protein 12 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006605 [protein targeting] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008179 [adenylate cyclase binding] GO:0010739 [positive regulation of protein kinase A signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0051018 [protein kinase A binding] GO:0090036 [regulation of protein kinase C signaling] Show all	1782 aa 191.5 kDa	No	0
AKAP12-002 ENSP00000346702 ENST00000354675	Q02952 [Direct mapping] A-kinase anchor protein 12 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006605 [protein targeting] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008179 [adenylate cyclase binding] GO:0010739 [positive regulation of protein kinase A signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0051018 [protein kinase A binding] GO:0090036 [regulation of protein kinase C signaling] Show all	1684 aa 181.7 kDa	No	0
AKAP12-201 ENSP00000352794 ENST00000359755	Q02952 [Direct mapping] A-kinase anchor protein 12 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006605 [protein targeting] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008179 [adenylate cyclase binding] GO:0010739 [positive regulation of protein kinase A signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0051018 [protein kinase A binding] GO:0090036 [regulation of protein kinase C signaling] Show all	1677 aa 181 kDa	No	0
AKAP12-202 ENSP00000384537 ENST00000402676	Q02952 [Direct mapping] A-kinase anchor protein 12 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0005938 [cell cortex] GO:0006605 [protein targeting] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008179 [adenylate cyclase binding] GO:0010739 [positive regulation of protein kinase A signaling] GO:0030819 [positive regulation of cAMP biosynthetic process] GO:0051018 [protein kinase A binding] GO:0090036 [regulation of protein kinase C signaling] Show all	1782 aa 191.5 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.