Expression of AAR2 in cancer - Summary - The Human Protein Atlas

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AAR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AAR2
Gene description	AAR2 splicing factor homolog
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 2 antibodies. HPA048645 , CAB034220
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048645	CAB034220

GENE INFORMATION
Gene name	AAR2 (HGNC Symbol)
Synonyms	bA234K24.2, C20orf4
Description	AAR2 splicing factor homolog (HGNC Symbol)
Entrez gene summary	This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	20
Cytoband	q11.23
Chromosome location (bp)	36236459 - 36270918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131043 (version 83.38)
Entrez gene	25980
UniProt	Q9Y312 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y312
Antibodypedia	AAR2 antibodies

PROTEIN BROWSER

AAR2-001	AAR2-002	AAR2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AAR2-001 ENSP00000363043 ENST00000373932	Q9Y312 [Direct mapping] Protein AAR2 homolog Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] Show all	384 aa 43.5 kDa	No	0
AAR2-002 ENSP00000380455 ENST00000397286	A2A2Q9 [Direct mapping] Protein AAR2 homolog Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] Show all	398 aa 45 kDa	No	0
AAR2-003 ENSP00000313674 ENST00000320849	Q9Y312 [Direct mapping] Protein AAR2 homolog Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000244 [spliceosomal tri-snRNP complex assembly] Show all	384 aa 43.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.