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NFATC1

GENERAL INFORMATION

Gene name

 NFATC1

Gene description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-698)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in a subset of lymphoid cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
CAB004513
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB004513

GENE INFORMATION

Gene name

 NFATC1 (HGNC Symbol)

Synonyms

 NF-ATC, NFAT2, NFATc

Description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

Chromosome

 18

Cytoband

 q23

Chromosome location (bp)

 79395856 - 79529325

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131196 (version 83.38)

Entrez gene

 4772

UniProt

 O95644 (UniProt - Evidence at protein level)

neXtProt

 NX_O95644

Antibodypedia

 NFATC1 antibodies

PROTEIN BROWSER
«
NFATC1-001
NFATC1-002
NFATC1-003
NFATC1-004
NFATC1-005
NFATC1-006
NFATC1-007
NFATC1-009
NFATC1-010
NFATC1-011
NFATC1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFATC1-001
ENSP00000253506
ENST00000253506
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 825 aa
88.8 kDa 		No 0
NFATC1-002
ENSP00000380892
ENST00000397790
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 353 aa
38.6 kDa 		No 0
NFATC1-003
ENSP00000316553
ENST00000318065
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 812 aa
87.9 kDa 		No 0
NFATC1-004
ENSP00000466194
ENST00000591814
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 716 aa
77.8 kDa 		No 0
NFATC1-005
ENSP00000468111
ENST00000587635
K7ER53 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 639 aa
69.4 kDa 		No 0
NFATC1-006
ENSP00000442435
ENST00000542384
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 713 aa
77.4 kDa 		No 0
NFATC1-007
ENSP00000389377
ENST00000427363
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 943 aa
101.2 kDa 		No 0
NFATC1-009
ENSP00000327850
ENST00000329101
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 930 aa
100.3 kDa 		No 0
NFATC1-010
ENSP00000466489
ENST00000586434
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 700 aa
76.5 kDa 		No 0
NFATC1-011
ENSP00000467181
ENST00000592223
O95644 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048273 [mitogen-activated protein kinase p38 binding]
Show all
 703 aa
76.9 kDa 		No 0
NFATC1-201
ENSP00000439992
ENST00000545796
F5H4S8 [Direct mapping]
Nuclear factor of-activated T-cells, cytoplasmic 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 471 aa
51.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.