Expression of HAUS8 in cancer - Summary - The Human Protein Atlas

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HAUS8

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HAUS8
Gene description	HAUS augmin-like complex, subunit 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA039406
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039406

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Malignant cells displayed strong cytoplasmic immunoreactivity, with a granular pattern.

GENE INFORMATION
Gene name	HAUS8 (HGNC Symbol)
Synonyms	HICE1, MGC20533, NY-SAR-48
Description	HAUS augmin-like complex, subunit 8 (HGNC Symbol)
Entrez gene summary	HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17049729 - 17075625
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131351 (version 83.38)
Entrez gene	93323
UniProt	Q9BT25 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BT25
Antibodypedia	HAUS8 antibodies

PROTEIN BROWSER

HAUS8-001	HAUS8-002	HAUS8-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAUS8-001 ENSP00000253669 ENST00000253669	Q9BT25 [Direct mapping] HAUS augmin-like complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005880 [nuclear microtubule] GO:0007067 [mitotic nuclear division] GO:0008017 [microtubule binding] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	410 aa 44.9 kDa	No	0
HAUS8-002 ENSP00000470829 ENST00000593360	Q9BT25 [Direct mapping] HAUS augmin-like complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005880 [nuclear microtubule] GO:0007067 [mitotic nuclear division] GO:0008017 [microtubule binding] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	349 aa 38.5 kDa	No	0
HAUS8-004 ENSP00000395298 ENST00000448593	Q9BT25 [Direct mapping] HAUS augmin-like complex subunit 8 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0003674 [molecular_function] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005880 [nuclear microtubule] GO:0007067 [mitotic nuclear division] GO:0008017 [microtubule binding] GO:0051225 [spindle assembly] GO:0051297 [centrosome organization] GO:0051301 [cell division] GO:0070652 [HAUS complex] Show all	409 aa 44.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.