Expression of CAPN7 in cancer - Summary - The Human Protein Atlas

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CAPN7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CAPN7
Gene description	Calpain 7
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA046617
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046617

GENE INFORMATION
Gene name	CAPN7 (HGNC Symbol)
Synonyms	PalBH
Description	Calpain 7 (HGNC Symbol)
Entrez gene summary	Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	15206152 - 15252918
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131375 (version 83.38)
Entrez gene	23473
UniProt	Q9Y6W3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6W3
Antibodypedia	CAPN7 antibodies

PROTEIN BROWSER

CAPN7-001	CAPN7-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPN7-001 ENSP00000253693 ENST00000253693	Q9Y6W3 [Direct mapping] Calpain-7 Show all	Enzymes Peptidases Cysteine-type peptidases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0010634 [positive regulation of epithelial cell migration] GO:0070062 [extracellular exosome] GO:0090541 [MIT domain binding] GO:0097264 [self proteolysis] Show all	813 aa 92.7 kDa	No	0
CAPN7-006 ENSP00000399486 ENST00000415565	H7C1B7 [Direct mapping] Calpain-7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0005622 [intracellular] GO:0006508 [proteolysis] Show all	248 aa 28.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.