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CAPN7

GENERAL INFORMATION

Gene name

 CAPN7

Gene description

 Calpain 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA046617
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CAPN7 (HGNC Symbol)

Synonyms

 PalBH

Description

 Calpain 7 (HGNC Symbol)

Entrez gene summary

 Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 15206152 - 15252918

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131375 (version 83.38)

Entrez gene

 23473

UniProt

 Q9Y6W3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6W3

Antibodypedia

 CAPN7 antibodies

PROTEIN BROWSER
CAPN7-001
CAPN7-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN7-001
ENSP00000253693
ENST00000253693
Q9Y6W3 [Direct mapping]
Calpain-7
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Enzymes
   Peptidases
   Cysteine-type peptidases
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0070062 [extracellular exosome]
GO:0090541 [MIT domain binding]
GO:0097264 [self proteolysis]
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 813 aa
92.7 kDa 		No 0
CAPN7-006
ENSP00000399486
ENST00000415565
H7C1B7 [Direct mapping]
Calpain-7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 248 aa
28.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.